A method of transvaginal colpo-urethropexy, using fibrin sealant was studied clinically. After a fingertip vaginal retropubic dissection, fibrin sealant is instilled in the retropubic space with the intent of inducing fibrosis between the elevated urethro-vesical junction and the retropubic periosteum. Twenty-three patients with urinary stress incontinence underwent this procedure with 82% of satisfactory results and 18% failure. Complications were minimal. In the future, this technique could be useful for ambulatory surgery.