Abstract
A rare case of hepatoblastoma in a 61-year-old Japanese housewife is described. This liver tumor mainly consisted of two tissue components: embryonal hepatocytes and primitive mesenchymal tissue. Fetal hepatocytes with alpha-fetoprotein production, gland formation, cartilage and osteoid were also found in a small portion. Molecular analysis by slot blot method revealed increased copy numbers of c-met and K-sam proto-oncogenes and cyclin D1 genes. These findings suggest that alterations of these oncogenes might play a role in the development of adult hepatoblastoma.
MeSH terms
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Cyclin D1
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Cyclins / metabolism
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Female
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Hepatoblastoma / etiology
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Hepatoblastoma / metabolism*
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Hepatoblastoma / pathology
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Hepatocyte Growth Factor / metabolism
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Humans
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Immunoblotting
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Immunohistochemistry
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Liver Neoplasms / etiology
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Liver Neoplasms / metabolism*
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Liver Neoplasms / pathology
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Middle Aged
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Oncogene Proteins / metabolism
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Proto-Oncogene Mas
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Proto-Oncogene Proteins c-met
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Receptor Protein-Tyrosine Kinases / metabolism*
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Receptor, Fibroblast Growth Factor, Type 2
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Receptors, Fibroblast Growth Factor / metabolism
Substances
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Cyclins
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MAS1 protein, human
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Oncogene Proteins
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Proto-Oncogene Mas
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Receptors, Fibroblast Growth Factor
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Cyclin D1
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Hepatocyte Growth Factor
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FGFR2 protein, human
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Proto-Oncogene Proteins c-met
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Receptor Protein-Tyrosine Kinases
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Receptor, Fibroblast Growth Factor, Type 2