Synthesis and biological activity of platinum group metal complexes of o-vanillin thiosemicarbazones

Abstract

o-Vanillin-(4-methylthiosemicarbazone), o-Vanillin-(4-phenylthiosemicarbazone) and some of their metal complexes of the platinum group have been synthesized, characterized by chemical and spectral methods and studied for their antibacterial, antifungal and amoebicidal activity in vitro. The platinum group metal chelates exibited significant activity against a wide spectrum of microorganisms at different concentrations. The Pt(II) and Ru(III) chelates derived from o-vanillin-(4-phenylthiosemicarbazone) seem to be the most efficient inhibitors. Evaluation of the antimalarial activity of the compounds in mice infected with Plasmodium berghei indicated that cures were attainable at dose levels of 40-160 mg/kg but with toxic death prevalence at higher dose levels.