[Combined treatment with factor VIII and immunosuppressive agents in a young woman with acquired factor VIII inhibitor]

Abstract

A twenty seven year-old woman is reported with severe haemorrhagic symptoms caused by an acquired coagulant factor VIII inhibitor eleven months after delivery. The inhibitor was quantified as 77 units according to the Bethesda method. Steroids treatment and high-dose immunoglobulins failed to elicit any response. Combined chemotherapy will cyclophosphamide, vincristine and prednisone after intravenous factor VIII, every fourth week, succeeded in eradicating the acquired inhibitor and progressively restoring the rates of factor VIII in this patient with acquired haemophilia.