Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239

J Virol. 1997 Mar;71(3):2522-7. doi: 10.1128/JVI.71.3.2522-2527.1997.

Abstract

We examined chemokine receptors for the ability to facilitate the infection of CD4-expressing cells by viruses containing the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239. Expression of either human or simian C-C chemokine receptor CCR5 allowed the SIVmac239 envelope glycoproteins to mediate virus entry and cell-to-cell fusion. Thus, distantly related immunodeficiency viruses such as SIV and the primary human immunodeficiency virus type 1 isolates can utilize CCR5 as an entry cofactor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • CD4-Positive T-Lymphocytes / immunology*
  • DNA, Viral
  • Gene Products, env / genetics
  • Gene Products, env / immunology*
  • HeLa Cells
  • Humans
  • Molecular Sequence Data
  • Receptors, CCR5
  • Receptors, Cytokine / immunology*
  • Receptors, HIV / immunology*
  • Simian Immunodeficiency Virus / genetics
  • Simian Immunodeficiency Virus / immunology
  • Simian Immunodeficiency Virus / isolation & purification
  • Simian Immunodeficiency Virus / physiology*

Substances

  • DNA, Viral
  • Gene Products, env
  • Receptors, CCR5
  • Receptors, Cytokine
  • Receptors, HIV

Associated data

  • GENBANK/U77672