The aim of the study was to make a selection of the calmodulin antagonists, which could be useful in topical treatment of psoriasis. Four drugs were assessed: chlorpromazine, trifluoperazine, miconazole and ketoconazole. They were applied on the skin of guinea pigs, twice a day for the period of two weeks. Biopsy specimens from these sites were being taken for light microscopy, histoenzymatic examination and for evaluation of the proliferation activity of the epidermis (the AgNOR stain, after Ploton). A decrease in reaction activities for lactate dehydrogenase and succinic dehydrogenase as well as in the proliferation activity of the epidermis, could suggest an inhibitory effect of chlorpromazine and miconazole on the cell cycle and keratinization process.