Escherichia coli strains currently recognized to cause human diarrhea can be distinguished on the basis of pathogenic mechanism and separated into five categories: enterotoxigenic (ETEC), enteroinvasive (EIEC), enterohemorrhagic (EHEC), enteroaggregative (EAggEC) and enteropathogenic (EPEC). EPEC is a bacterial pathogen that causes diarrhea in infants, particularly in developing countries. The purpose of this review is to summarize recent advances in the understanding of EPEC pathogenesis and the contribution of Mexican investigators to the knowledge of this pathogen.