Abstract
Twenty-six derivatives of harmaline and tetrahydroharmine were prepared and characterized by UV, IR, MS, and NMR spectroscopy. They were tested for their antimicrobial, antiplatelet aggregation and cytotoxic activity. Their effect on central nervous system was also studied.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Bacteria / drug effects
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Carbolines / chemical synthesis
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Carbolines / chemistry*
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Carbolines / pharmacology*
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Central Nervous System Agents / chemical synthesis
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Central Nervous System Agents / pharmacology
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Drug Screening Assays, Antitumor
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Harmaline / analogs & derivatives*
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Harmaline / chemical synthesis*
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Harmaline / pharmacology
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Humans
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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Microbial Sensitivity Tests
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Platelet Aggregation Inhibitors / chemical synthesis
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Platelet Aggregation Inhibitors / pharmacology
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Tryptamines / chemical synthesis
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Tryptamines / chemistry*
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Tryptamines / pharmacology*
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Carbolines
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Central Nervous System Agents
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Platelet Aggregation Inhibitors
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Tryptamines
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Harmaline