Abstract
Evidences are given that implantation of human apo A-I gene to experimental animals induces essential changes in the functional state of hepatocyte plasmatic phospholipid composition, hyperpolarization development, as well as changes in the Na, K-ATPase and adenylate cyclase activities. The presence of generalized cell reaction is evidenced from the fact than biosynthesis of summary proteins gets enhanced during the above changes.
MeSH terms
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Adenylyl Cyclases / metabolism
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Animals
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Apolipoprotein A-I / genetics*
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Cell Membrane / genetics
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Cell Membrane / metabolism
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Gene Expression Regulation / physiology*
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Gene Transfer Techniques*
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Humans
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Liposomes
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Liver / metabolism*
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Membrane Lipids / metabolism
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Membrane Proteins / metabolism
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Rats
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Rats, Wistar
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Sodium-Potassium-Exchanging ATPase / metabolism
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Time Factors
Substances
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Apolipoprotein A-I
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Liposomes
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Membrane Lipids
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Membrane Proteins
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Adenylyl Cyclases
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Sodium-Potassium-Exchanging ATPase