Abstract
Two new triterpenoid saponins named asterlingulatosides A and B were isolated from the whole plants of Aster lingulatus. Their structures were determined by spectroscopic data and chemical transformations to be 3-O-beta-D-glucopyranosyl-3 beta,16 alpha-dihydroxyolean-12-en-28-oic acid-28-O-alpha-L-O-arabinopyranoside and 3-O-beta-D-glucopyranosyl-3 beta,16 alpha-dihydroxyolean-12-en-28-oic acid-28-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside++ +. They showed inhibitory activity on DNA synthesis in human leukaemia HL-60 cells.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / toxicity
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Carbohydrate Conformation
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Carbohydrate Sequence
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DNA Replication / drug effects
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HL-60 Cells
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Humans
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Molecular Sequence Data
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Molecular Structure
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Oleanolic Acid* / analogs & derivatives*
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Plant Extracts
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Plants*
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Saponins / chemistry*
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Saponins / isolation & purification
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Saponins / toxicity
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Thymidine / metabolism
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Triterpenes / chemistry*
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Triterpenes / toxicity
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Saponins
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Triterpenes
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asterlingulatoside A
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asterlingulatoside B
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Oleanolic Acid
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Thymidine