Abstract
Experimental hypertension was induced in rats by two methods. In the course of hypertension development the rats of experimental groups were treated with following tricyclic antidepressive agents: Imipramine, Opipramol, Amitriptylline and Nortriptylline injected in doses of 5.0 or 0.5 mg per 1 kg of body weight. Higher doses of the above drugs inhibited the development of hypertension, whereas the lower doses had no effect on arterial blood pressure.
MeSH terms
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Animals
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Antidepressive Agents / administration & dosage
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Antidepressive Agents / pharmacology*
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Antidepressive Agents / therapeutic use
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Aorta / metabolism
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Blood Pressure / drug effects*
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Brain Chemistry
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Catecholamines / antagonists & inhibitors
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Catecholamines / metabolism*
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Catecholamines / urine
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Dose-Response Relationship, Drug
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Heart Rate / drug effects
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Hypertension / drug therapy*
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Hypertension / physiopathology
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Myocardium / metabolism
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Rats
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Vascular Resistance / drug effects
Substances
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Antidepressive Agents
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Catecholamines