The peroxisome proliferator-activated receptors: ligands and activators

Ann N Y Acad Sci. 1996 Dec 27:804:266-75. doi: 10.1111/j.1749-6632.1996.tb18621.x.

Abstract

PPAR alpha and PPAR gamma represent related but distinct members of the nuclear receptor superfamily. PPAR alpha signaling is modulated by long-chain fatty acids, whereas PPAR gamma ligands are potent antidiabetic agents.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fatty Acids / chemistry
  • Fatty Acids / pharmacology
  • Gene Expression Regulation, Enzymologic
  • Ligands
  • Mice
  • Microbodies / drug effects*
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Rosiglitazone
  • Signal Transduction
  • Structure-Activity Relationship
  • Thiazoles / pharmacology
  • Thiazolidinediones*
  • Transcription Factors / physiology*

Substances

  • Fatty Acids
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Thiazoles
  • Thiazolidinediones
  • Transcription Factors
  • Rosiglitazone