Cytotoxic amides from the octocoral Telesto riisei

G K Liyanage; F J Schmitz

doi:10.1021/np960032t

Cytotoxic amides from the octocoral Telesto riisei

J Nat Prod. 1996 Feb;59(2):148-51. doi: 10.1021/np960032t.

Authors

G K Liyanage¹, F J Schmitz

Affiliation

¹ Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.

PMID: 8991947
DOI: 10.1021/np960032t

Abstract

Two new acyl derivatives of beta-phenylethylamine, N-(2-phenylethyl)-9- oxohexadecacarboxamide (1) and N-(2-phenylethyl)-9-hydroxyhexadecacarboxamide (2), and two new tetrahydroxysterols, cholestane-3 beta, 5 alpha,6 beta-26-tetrol 27-acetate (3) and cholestane-3 beta, 5 alpha, 6 beta-26-tetrol (4), have been isolated from the coelenterate Telesto riisei collected in Chuuk, Federated States of Micronesia. Structures were determined from spectroscopic data. All new compounds were mildly toxic to murine leukemia cells (P-388) in culture.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Amides / isolation & purification*
Amides / toxicity*
Animals
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / toxicity*
Cnidaria / chemistry*
Drug Screening Assays, Antitumor
Leukemia P388 / drug therapy
Mice
Micronesia
Tumor Cells, Cultured

Substances

Amides
Antineoplastic Agents