Carbazole alkaloids from Clausena excavata and their biological activity

Phytochemistry. 1996 Sep;43(1):133-40. doi: 10.1016/0031-9422(96)00212-9.

Abstract

Five new carbazole alkaloids, clausines B, E, H, I and K, as well as 22 known compounds, were isolated from the stem bark of Clausena excavata. The structures were established from spectral data and chemical transformation. These compounds showed significant inhibition of rabbit platelet aggregation and caused vasocontraction. The crude methanol extract, partitioned layers and chromatographic fractions revealed the presence of promotive and inhibitive constituents, simultaneously. These results might explain the philosophy of use in Chinese medicine, in that the dose and content variation in a prescription produced different, promotive or inhibitive, effects on therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Medicine, Chinese Traditional
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Platelet Aggregation Inhibitors / chemistry
  • Platelet Aggregation Inhibitors / isolation & purification*
  • Platelet Aggregation Inhibitors / pharmacology
  • Rabbits
  • Spectrophotometry, Ultraviolet
  • Vasoconstrictor Agents / chemistry
  • Vasoconstrictor Agents / isolation & purification*
  • Vasoconstrictor Agents / pharmacology

Substances

  • Alkaloids
  • Platelet Aggregation Inhibitors
  • Vasoconstrictor Agents