Abstract
A new quassinoid, 11-O-trans-p-coumaroyl amarolide (1) was isolated from Castela texana, and the structure was elucidated by spectroscopic analysis. Compound 1 is the first coumaroyl quassinoid derivative to have been isolated from nature. The known compounds amarolide (2), chaparrinone, chaparrin, glaucarubolone, holacanthone, and 15-O-beta-D-glucopyranosyl glaucarubol were also isolated. All isolated compounds were tested for their cytotoxicity and antiprotozoal activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / pharmacology
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Antiprotozoal Agents / isolation & purification*
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Antiprotozoal Agents / pharmacology
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Giardia / drug effects
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Mexico
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Plants, Medicinal / chemistry*
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Plasmodium falciparum / drug effects
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Texas
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
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Trypanocidal Agents / pharmacology
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Tumor Cells, Cultured
Substances
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11-O-4-coumaroyl amarolide
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Antimalarials
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Antineoplastic Agents, Phytogenic
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Antiprotozoal Agents
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Triterpenes
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Trypanocidal Agents