Molecular structure of terrecyclodiol: a derivative of the antifungal metabolite terrecyclic acid A from Aspergillus terreus

F Almassi; E L Ghisalberti; B W Skelton; A H White

doi:10.1021/np960008f

Molecular structure of terrecyclodiol: a derivative of the antifungal metabolite terrecyclic acid A from Aspergillus terreus

J Nat Prod. 1996 Jan;59(1):59-61. doi: 10.1021/np960008f.

Authors

F Almassi¹, E L Ghisalberti, B W Skelton, A H White

Affiliation

¹ Department of Chemistry, University of Western Australia, Nedlands.

PMID: 8984154
DOI: 10.1021/np960008f

Abstract

A strain of Aspergillus terreus, which was isolated from organic mulch and inhibited the growth of the plant pathogen Phytophthora cinnamomi, produces an antifungal metabolite when grown in liquid culture. This metabolite was isolated by bioassay-guided fractionation and identified as terrecyclic acid A (1). X-ray diffraction studies and spectroscopic details of the derived terrecyclodiol (2) are described.

MeSH terms

Antifungal Agents / chemistry*
Antifungal Agents / isolation & purification
Aspergillus / chemistry*
Aspergillus / metabolism
Crystallization
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Conformation
Phytophthora / drug effects
Sesquiterpenes / chemistry*
Sesquiterpenes / metabolism
Sesquiterpenes / pharmacology
X-Ray Diffraction

Substances

Antifungal Agents
Sesquiterpenes
terrecyclodiol
terrecyclic acid A