Abstract
The first examples of PEG linkers containing the highly fluorescent dansyl group have been synthesized. Quantum yields of these PEG fluorescent linkers (PFL) were determined and utilized in calculating the PEG number of various protein conjugates. The method was also shown to be applicable to lower molecular weight drugs as exemplified by taxol.
MeSH terms
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Animals
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Cattle
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Dansyl Compounds / chemical synthesis
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Dansyl Compounds / chemistry
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Fluorescent Dyes / chemical synthesis*
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Fluorescent Dyes / chemistry
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Molecular Structure
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Paclitaxel / chemistry
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Polyethylene Glycols / chemical synthesis*
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Polyethylene Glycols / chemistry
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Proteins / chemistry
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Serum Albumin, Bovine / chemistry
Substances
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Dansyl Compounds
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Fluorescent Dyes
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Proteins
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Serum Albumin, Bovine
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Polyethylene Glycols
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Paclitaxel