A 30 year-old man with acquired immunodeficiency syndrome was admitted because of abdominal pain, jaundice and fever. A severe pancreatitis without gallstones was detected. Later, dilation of biliary tract and clinical worsening appeared. Cholangiography revealed sclerosing cholangitis and papillary stenosis. Kaposi's sarcoma of the gallbladder invading the biliary tract was found. Only two reports of Kaposi's sarcoma of the biliary tract without cutaneous lesions have been published in a living patient. Pancreatitis has not been previously described as a clinical presentation of this malignancy.