Abstract
Physico-chemical and microbiological properties of three different forms (crystalline and two amorphous ones) of the 1-acetoxyethyl ester of cefuroxime and bioavailability after oral administration to rats have been investigated. Relation between physico-chemical properties of these forms and their bioavailability is observed. It is shown, that for oral administration the most appropriate is an amorphous form obtained by rapid evaporation of a solvent from solution of the ester.
MeSH terms
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Animals
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Area Under Curve
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Biological Availability
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Cefuroxime / analogs & derivatives*
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Cefuroxime / chemistry
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Cefuroxime / pharmacokinetics
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Cefuroxime / pharmacology
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Cephalosporins / chemistry
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Cephalosporins / pharmacokinetics*
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Cephalosporins / pharmacology*
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Escherichia coli / drug effects
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Half-Life
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Male
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Microbial Sensitivity Tests
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Prodrugs / pharmacokinetics*
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Prodrugs / pharmacology*
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Rats
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Rats, Wistar
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Staphylococcus aureus / drug effects
Substances
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Cephalosporins
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Prodrugs
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Cefuroxime
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cefuroxime axetil