Betulinans A and B, two benzoquinone compounds from Lenzites betulina

I K Lee; B S Yun; S M Cho; W G Kim; J P Kim; I J Ryoo; H Koshino; I D Yoo

doi:10.1021/np960253z

Betulinans A and B, two benzoquinone compounds from Lenzites betulina

J Nat Prod. 1996 Nov;59(11):1090-2. doi: 10.1021/np960253z.

Authors

I K Lee¹, B S Yun, S M Cho, W G Kim, J P Kim, I J Ryoo, H Koshino, I D Yoo

Affiliation

¹ Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea.

PMID: 8946751
DOI: 10.1021/np960253z

Abstract

Two lipid peroxidation inhibitors, designated as betulinans A (1) and B (2), were isolated from the MeOH extract of Lenzites betulina. The structures of these compounds have been determined to be 2,5-diphenyl-3,6-dimethoxy-p-benzoquinone and 2-phenyl-3-methoxy-[1H-2-benzopyran][4,3-e][p]benzoquinone, respectively, on the basis of various spectral data. Betulinans A and B inhibited lipid peroxidation with IC50 values of 0.46 and 2.88 micrograms/mL, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antioxidants / isolation & purification*
Antioxidants / pharmacology
Benzoquinones / isolation & purification*
Benzoquinones / pharmacology
In Vitro Techniques
Lipid Peroxidation / drug effects
Magnetic Resonance Spectroscopy
Microsomes, Liver / drug effects
Microsomes, Liver / metabolism
Polyporaceae / chemistry*
Rats
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Vitamin E / pharmacology

Substances

Antioxidants
Benzoquinones
betulinan A
betulinan B
Vitamin E