Recent major developments in the Louisiana Tumor Registry (LTR) have enhanced the operation of LTR and broadened its available services. As a population-based cancer registry, the LTR assesses the magnitude of cancer burden in the state, identifies high-risk groups and areas, monitors time trends, evaluated cancer control programs, and provides resources to the health professionals in the state to address the considerable cancer problem in Louisiana. The registry is also available to provide research collaboration as well as to participate in cancer control and prevention programs.