We describe the case of a patient who presented with abdominal pain, weight loss, and night sweats of 8 wk duration due to the impalement of a toothpick in the transverse colon. The toothpick, which was inadvertently swallowed, was successfully removed during colonoscopy. Therapeutic colonoscopy has replaced or lessened to a significant degree the need for traditional open surgical procedures to extract foreign bodies from the colon. Unexplained abdominal pain and constitutional symptoms should alert the clinician to the possibility of a foreign body.