Hypomelanosis of Ito and brain abnormalities: MRI findings and literature review

Pediatr Radiol. 1996 Nov;26(11):763-8. doi: 10.1007/BF01396196.

Abstract

We report the results of a 14-year retrospective study of brain MRI abnormalities in 12 pediatric patients presenting with hypomelanosis of Ito (HI). Miscellaneous brain abnormalities were found: one patient had a medulloblastoma, three had cortical malformations, and five demonstrated "minor" abnormalities such as dilated Virchow-Robin spaces or brain atrophy. We emphasize the polymorphism of brain abnormalities associated with HI.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Atrophy
  • Brain / abnormalities*
  • Brain / pathology
  • Brain Neoplasms / complications
  • Brain Neoplasms / diagnosis
  • Cerebral Ventricles / pathology
  • Child
  • Child, Preschool
  • Dilatation, Pathologic / complications
  • Dilatation, Pathologic / diagnosis
  • Female
  • Humans
  • Hypertrophy
  • Hypopigmentation / complications
  • Infant
  • Magnetic Resonance Imaging*
  • Male
  • Medulloblastoma / complications
  • Medulloblastoma / diagnosis
  • Pigmentation Disorders / complications*
  • Polymorphism, Genetic
  • Retrospective Studies
  • Tomography, X-Ray Computed