Abstract
The genotype for N-acetyltransferase was analyzed in five Japanese patients with isoniazid neuropathy by using the allele specific polymerase chain reaction for a single slice of the 30-year-old paraffin-embedded and hematoxylin-eosin stained sural nerve biopsy specimens. We found slow acetylator genotypes for N-acetyltransferase in all isoniazid neuropathy patients. This result confirmed that patients with the slow acetylator genotype tend to develop neuropathy after administration of isoniazid.
MeSH terms
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Acetylation / drug effects
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Alleles
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Antitubercular Agents / adverse effects*
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Arylamine N-Acetyltransferase / genetics
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Arylamine N-Acetyltransferase / metabolism*
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Base Sequence
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Biopsy
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DNA Primers / genetics
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Eosine Yellowish-(YS)
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Genotype
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Hematoxylin
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Humans
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Isoniazid / adverse effects*
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Mutation / physiology
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Paraffin Embedding
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Peripheral Nervous System Diseases / chemically induced
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Peripheral Nervous System Diseases / enzymology
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Peripheral Nervous System Diseases / genetics*
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Polymerase Chain Reaction
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Sural Nerve / enzymology*
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Sural Nerve / physiopathology
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Time Factors
Substances
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Antitubercular Agents
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DNA Primers
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Arylamine N-Acetyltransferase
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Eosine Yellowish-(YS)
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Isoniazid
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Hematoxylin