Abstract
The anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD50 of t-DCTN was 555.0 mg/kg (p.o.) for mice.
MeSH terms
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Analgesics / isolation & purification
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Analgesics / pharmacology*
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Analgesics / toxicity
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Brazil
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Diterpenes / toxicity
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Diterpenes, Clerodane*
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Granuloma
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Lethal Dose 50
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Male
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Mice
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Morphine / pharmacology
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Pain
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Plants, Medicinal*
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Rats
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Rats, Wistar
Substances
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Analgesics
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Anti-Inflammatory Agents, Non-Steroidal
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Diterpenes
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Diterpenes, Clerodane
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dehydrocrotonin
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Morphine