Effect of 17 alpha-ethinylestradiol, levonorgestrel, 3-keto-desogestrel, and gestodene on calcium influx via voltage-gated calcium channels in human aortic smooth muscles

Contraception. 1996 Oct;54(4):265-8. doi: 10.1016/s0010-7824(96)00188-6.

Abstract

The effect of the synthetic estradiol, 17 alpha-ethinylestradiol, and three progestogens on calcium influx was investigated in cell cultures of human aortic smooth muscle. Neither the synthetic estrogen nor the progestogens levonorgestrel, 3-keto-desogestrel, and gestodene showed, in the concentration range of 10(-9) to 10(-6) M, a significant effect on calcium influx both alone or in equimolar estrogen-gestagen combinations. The results indicate that these substances, commonly used in contraceptive pills, do not change vasotonus interfering with calcium homeostasis.

Publication types

  • Comparative Study

MeSH terms

  • Aorta
  • Calcium / analysis
  • Calcium / metabolism*
  • Calcium Channels / drug effects
  • Calcium Channels / metabolism*
  • Calcium Radioisotopes
  • Cells, Cultured
  • Desogestrel / pharmacology
  • Dose-Response Relationship, Drug
  • Estradiol Congeners / pharmacology*
  • Ethinyl Estradiol / pharmacology*
  • Humans
  • Levonorgestrel / pharmacology
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / metabolism*
  • Norpregnenes / pharmacology
  • Progesterone Congeners / pharmacology*

Substances

  • Calcium Channels
  • Calcium Radioisotopes
  • Estradiol Congeners
  • Norpregnenes
  • Progesterone Congeners
  • Gestodene
  • etonogestrel
  • Ethinyl Estradiol
  • Levonorgestrel
  • Desogestrel
  • Calcium