Abstract
The effect of the synthetic estradiol, 17 alpha-ethinylestradiol, and three progestogens on calcium influx was investigated in cell cultures of human aortic smooth muscle. Neither the synthetic estrogen nor the progestogens levonorgestrel, 3-keto-desogestrel, and gestodene showed, in the concentration range of 10(-9) to 10(-6) M, a significant effect on calcium influx both alone or in equimolar estrogen-gestagen combinations. The results indicate that these substances, commonly used in contraceptive pills, do not change vasotonus interfering with calcium homeostasis.
MeSH terms
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Aorta
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Calcium / analysis
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Calcium / metabolism*
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Calcium Channels / drug effects
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Calcium Channels / metabolism*
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Calcium Radioisotopes
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Cells, Cultured
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Desogestrel / pharmacology
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Dose-Response Relationship, Drug
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Estradiol Congeners / pharmacology*
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Ethinyl Estradiol / pharmacology*
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Humans
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Levonorgestrel / pharmacology
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Muscle, Smooth, Vascular / cytology
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Muscle, Smooth, Vascular / drug effects
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Muscle, Smooth, Vascular / metabolism*
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Norpregnenes / pharmacology
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Progesterone Congeners / pharmacology*
Substances
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Calcium Channels
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Calcium Radioisotopes
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Estradiol Congeners
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Norpregnenes
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Progesterone Congeners
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Gestodene
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etonogestrel
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Ethinyl Estradiol
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Levonorgestrel
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Desogestrel
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Calcium