Abstract
Antisera against a rat brain synaptic protein preparation, the postsynaptic density (PSD) fraction, were used to isolate cDNA clones by expression screening of a rat brain cDNA library. About one fifth of more than 200 analyzed cDNAs encoding potential synapse-associated proteins were previously unknown. Identifiable proteins include, among others, components of the pre- and postsynaptic cytoskeleton, synaptic vesicle proteins and several protein kinases and kinase substrates. This demonstrates that both pre- and postsynaptic elements purify with the PSD fraction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Chemistry / physiology*
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Cloning, Molecular
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Connexins / analysis*
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Cytoskeletal Proteins / analysis
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DNA, Complementary / isolation & purification
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Extracellular Matrix Proteins / analysis
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Membrane Proteins / analysis
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Molecular Sequence Data
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Nerve Tissue Proteins / analysis*
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Protein Kinases / analysis
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Rats
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Synapses / chemistry*
Substances
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Connexins
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Cytoskeletal Proteins
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DNA, Complementary
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Extracellular Matrix Proteins
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Membrane Proteins
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Nerve Tissue Proteins
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Protein Kinases
Associated data
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GENBANK/X94486
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GENBANK/X94497
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GENBANK/X94498
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GENBANK/X94499
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GENBANK/X94500
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GENBANK/X94501
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GENBANK/X94502
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GENBANK/X94503
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GENBANK/X94504
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GENBANK/X94505
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GENBANK/X94506
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GENBANK/X94507
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GENBANK/X94508
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GENBANK/X94509
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GENBANK/X94510
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GENBANK/X94511
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GENBANK/X94512
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GENBANK/X94513
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GENBANK/X94514
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GENBANK/X94516
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GENBANK/X94517
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GENBANK/X94519
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GENBANK/X94520
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GENBANK/X94521
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GENBANK/X94522
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GENBANK/X94523
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GENBANK/X94524
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GENBANK/X94525