Abstract
Novel potent regulators of tumor necrosis factor alpha (TNF-alpha) production by a human promyelocytic leukemia cell line, HL-60, were prepared. All the compounds showed inducer-specific and bidirectional regulation of TNF-alpha production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate-induced TNF-alpha production, while they inhibited okadaic acid-induced one.
MeSH terms
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Carcinogens / antagonists & inhibitors
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Carcinogens / pharmacology
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Drug Synergism
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HL-60 Cells
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Humans
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Okadaic Acid / antagonists & inhibitors
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Okadaic Acid / pharmacology
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Phthalimides / chemical synthesis*
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Phthalimides / pharmacology
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Stimulation, Chemical
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Tetradecanoylphorbol Acetate / pharmacology
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Tumor Necrosis Factor-alpha / biosynthesis*
Substances
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Carcinogens
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Phthalimides
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Tumor Necrosis Factor-alpha
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Okadaic Acid
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Tetradecanoylphorbol Acetate