Inducer-specific regulators of tumor necrosis factor alpha production

Chem Pharm Bull (Tokyo). 1996 Oct;44(10):1980-2. doi: 10.1248/cpb.44.1980.

Abstract

Novel potent regulators of tumor necrosis factor alpha (TNF-alpha) production by a human promyelocytic leukemia cell line, HL-60, were prepared. All the compounds showed inducer-specific and bidirectional regulation of TNF-alpha production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate-induced TNF-alpha production, while they inhibited okadaic acid-induced one.

MeSH terms

  • Carcinogens / antagonists & inhibitors
  • Carcinogens / pharmacology
  • Drug Synergism
  • HL-60 Cells
  • Humans
  • Okadaic Acid / antagonists & inhibitors
  • Okadaic Acid / pharmacology
  • Phthalimides / chemical synthesis*
  • Phthalimides / pharmacology
  • Stimulation, Chemical
  • Tetradecanoylphorbol Acetate / pharmacology
  • Tumor Necrosis Factor-alpha / biosynthesis*

Substances

  • Carcinogens
  • Phthalimides
  • Tumor Necrosis Factor-alpha
  • Okadaic Acid
  • Tetradecanoylphorbol Acetate