Abstract
The effects of in vivo lipopolysaccharide administration on serum lipid metabolism were studied in normal and hepatoma-bearing rats. Changes in serum lipid levels and adipose tissue lipase (lipoprotein lipase and hormone-sensitive lipase) activities following injection of lipopolysaccharide into normal rats resembled those in hepatoma-bearing rats. These results suggest the presence of some common factor(s) involved in the incidence of abnormal lipid metabolism upon lipopolysaccharide injection and hepatoma transplantation.
MeSH terms
-
Adipose Tissue / drug effects
-
Adipose Tissue / enzymology*
-
Animals
-
Hyperlipidemias / blood
-
Hyperlipidemias / enzymology
-
Hyperlipidemias / metabolism
-
Lipids / blood*
-
Lipopolysaccharides / toxicity*
-
Lipoprotein Lipase / drug effects
-
Lipoprotein Lipase / metabolism*
-
Liver Neoplasms, Experimental / blood
-
Liver Neoplasms, Experimental / enzymology
-
Liver Neoplasms, Experimental / metabolism*
-
Male
-
Rats
-
Rats, Inbred Strains
-
Tumor Necrosis Factor-alpha / pharmacology
Substances
-
Lipids
-
Lipopolysaccharides
-
Tumor Necrosis Factor-alpha
-
Lipoprotein Lipase