We examined the acidophilic oval structures which were frequently encountered in the trigeminal ganglia of cattle that clinically showed trigeminal disturbance. Histopathologically, these structures were composed of numerous fine granules and were generally located near the neuronal cell bodies. They were demonstrated in silver preparations and, using neuron-specific enolase, tau and ubiquitin antibodies. Electron microscopy revealed an accumulation of large membranous vesicles thought to be derived from the smooth endoplasmic reticulum of axons, a few degenerative mitochondria and non-membrane-bound osmiophilic debris. Such pathological alterations were consistent with degenerative axonal changes or enlargements, although the pathogenesis was not clear. It should be emphasized that such axonal degeneration is frequently observed as a nonspecific reaction in the trigeminal ganglia in various diseases that cause trigeminal failure in cattle.