Abstract
1. Activation of sensory neurons at 2 Hz for 15 min induces long-term depression (LTD) of isolated Aplysia sensorimotor synapses in cell culture. 2. Prior infusion of the Ca2+ chelator 1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid (BAPTA) into the postsynaptic motor neuron blocks the induction of LTD, but not short-term synaptic depression. 3. Invertebrate central synapses possess the capacity for LTD. This form of long-term synaptic plasticity may play an important role in learning in Aplysia.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Aplysia / physiology*
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Calcium / physiology*
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Cells, Cultured
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Chelating Agents / pharmacology
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Egtazic Acid / analogs & derivatives
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Egtazic Acid / pharmacology
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Electrophysiology
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Ganglia, Invertebrate / cytology
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Ganglia, Invertebrate / drug effects
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Motor Neurons / drug effects
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Motor Neurons / physiology*
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Neuronal Plasticity / drug effects
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Neuronal Plasticity / physiology*
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Neurons, Afferent / drug effects
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Neurons, Afferent / physiology*
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Synapses / drug effects
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Synapses / physiology*
Substances
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Chelating Agents
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Egtazic Acid
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1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
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Calcium