Abstract
In an ongoing survey of the bioactive potential of microorganisms associated with marine invertebrates, the culture media of a sponge-associated bacterial strain of Pseudomonas aeruginosa was found to contain metabolites which inhibit the growth of several Gram-positive microorganisms. A series of diketopiperazines (1-6) including a new natural product (6) and two known phenazine alkaloid antibiotics (7 and 8) were isolated from the culture broth of this bacterium.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkaloids / biosynthesis
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antarctic Regions
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Anti-Bacterial Agents / biosynthesis
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Bacteria / drug effects*
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Culture Media
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Piperazines / isolation & purification*
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Piperazines / metabolism
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Piperazines / pharmacology
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Porifera / microbiology*
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Pseudomonas aeruginosa / isolation & purification
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Pseudomonas aeruginosa / metabolism*
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Spectrometry, Mass, Fast Atom Bombardment
Substances
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Alkaloids
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Anti-Bacterial Agents
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Culture Media
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Piperazines