One hundred (39 women and 61 men) hospitalized substance abusers were administered the MMPI and MMPI-2. The correspondence of T-Scores, Codetypes, and MAC/MAC-R scores were analyzed. Results showed that the MMPI-2 produced profiles that were consistent with previous research on the MMPI with substance abusers. However, the relationship between MMPI and MMPI-2 T-scores appeared complex and varied across individual scales for both men and women. Codetype congruence was 38% for one, two, and three-point code-types. Well-defined codetypes accounted for 30% of the profiles. MAC/ MAC-R raw scores were different for men but not for women. Codetypes established for the MMPI may not be fully transferable to the MMPI-2 in a substance abusing population.