Inhibition of mitochondrial cytochrome C oxidase by dicarbanonaborates

Biochem Mol Biol Int. 1996 Aug;39(6):1267-73. doi: 10.1080/15216549600201462.

Abstract

Dicarbanonaborates inhibit the mitochondrial cytochrome c oxidase activity. In contrast to mitochondrial ATPase or glycerol phosphate dehydrogenase, inhibition of cytochrome c oxidase was not competitive and the residual, drug-insensitive activity was higher. These results indicate that dicarbanonaborates inhibit various mitochondrial membrane-bound enzymes through different mechanisms.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / antagonists & inhibitors
  • Animals
  • Borates / pharmacology*
  • Electron Transport Complex IV / antagonists & inhibitors*
  • Glycerolphosphate Dehydrogenase / antagonists & inhibitors
  • Mitochondria, Liver / drug effects*
  • Mitochondria, Liver / enzymology
  • Rats

Substances

  • Borates
  • Glycerolphosphate Dehydrogenase
  • Electron Transport Complex IV
  • Adenosine Triphosphatases