Abstract
2,4-Disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives 5-13 were synthesized and evaluated for their pharmacological activity. Compounds 5, 7, 9, 10 and 12 showed antiaggressive effect, compounds 6 and 10 showed synergism with hexobarbital while compound 6 exerted analgesic activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5-Hydroxytryptophan / pharmacology
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Aggression / drug effects
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Analgesics, Non-Narcotic / chemical synthesis
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Analgesics, Non-Narcotic / pharmacology
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Animals
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Apomorphine / pharmacology
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Carboxylic Acids / chemical synthesis*
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Carboxylic Acids / pharmacology
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Carboxylic Acids / toxicity
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Dopamine Agonists / pharmacology
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Drug Interactions
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Female
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Hexobarbital / pharmacology
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Hypnotics and Sedatives / pharmacology
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Lethal Dose 50
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Motor Activity / drug effects
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Pain Measurement / drug effects
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Psychotropic Drugs / chemical synthesis*
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Psychotropic Drugs / pharmacology
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Psychotropic Drugs / toxicity
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology
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Pyrimidines / toxicity
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Rats
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Rats, Wistar
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Reaction Time / drug effects
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Reserpine / antagonists & inhibitors
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Sleep / drug effects
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Stereotyped Behavior / drug effects
Substances
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Analgesics, Non-Narcotic
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Carboxylic Acids
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Dopamine Agonists
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Hypnotics and Sedatives
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Psychotropic Drugs
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Pyrimidines
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Reserpine
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Hexobarbital
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5-Hydroxytryptophan
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Apomorphine