Kinetics of anhydride formation in xerogels of poly(acrylic acid)

Biomaterials. 1996 Sep;17(17):1667-75. doi: 10.1016/0142-9612(96)87646-0.

Abstract

The aim of this work was to study the cross-linkage of xerogels made of Carbopol of different molecular weight (polymers deriving from polyacrylic acid), and the influence exerted by different percentages of beta-cyclodextrin upon the cross-linkage percentage. Xerogels were obtained by high-pressure compression and cross-linking was studied by measuring the weight loss of different formulations over a temperature range of 70 to 190 degrees C. Kinetics of anhydride formation were found to follow a second-order mechanism with an activation energy of approximately 25 kcal mol-1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry*
  • Anhydrides / chemical synthesis
  • Calorimetry, Differential Scanning
  • Cross-Linking Reagents / chemistry
  • Cyclodextrins / analysis
  • Cyclodextrins / chemistry
  • Drug Carriers / chemical synthesis*
  • Gels / chemical synthesis*
  • Kinetics
  • Mathematics
  • Molecular Weight
  • Polyvinyls / chemical synthesis*
  • beta-Cyclodextrins*

Substances

  • Acrylic Resins
  • Anhydrides
  • Cross-Linking Reagents
  • Cyclodextrins
  • Drug Carriers
  • Gels
  • Polyvinyls
  • beta-Cyclodextrins
  • carboxypolymethylene
  • carbopol 940
  • betadex