Lithiation-based silylation and stannylation of 6-chloro-9-(beta-D-ribofuranosyl)purine

K Katoh; H Hayakawa; H Tanaka; H Kumamoto; T Miyasaka

Lithiation-based silylation and stannylation of 6-chloro-9-(beta-D-ribofuranosyl)purine

Nucleic Acids Symp Ser. 1995:(34):155-6.

Authors

K Katoh¹, H Hayakawa, H Tanaka, H Kumamoto, T Miyasaka

Affiliation

¹ School of Pharmaceutical Sciences, Showa University, Japan.

PMID: 8841599

Abstract

Reaction of the lithiated species of 9-(2,3,5-tris-O-tert-butyldimethylsilyl-beta-D-ribofuranosyl)-6-chloropu rine with Me3SiCl or Bu3SnCl was found to furnish the corresponding C-2 substituted product, as a result of silyl or stannyl migration from C-8 to C-2 position.

MeSH terms

Electrochemistry
Indicators and Reagents
Lithium / chemistry
Methods
Molecular Structure
Purine Nucleosides / chemical synthesis*
Purine Nucleosides / chemistry*
Silicon / chemistry
Tin / chemistry

Substances

Indicators and Reagents
Purine Nucleosides
6-chloropurine riboside
Tin
Lithium
Silicon