The authors' method of long-lasting pancreatic cannulation from the side of the duodenal papilla was compared with the method of accessory pancreatic duct direct cannulation in 20 pigs divided into two groups of 10 animals each. The volume of pancreatic juice was determined in both groups. In addition, the parameters of acid-base equilibrium in whole blood and the values of Na+, K+, Cl-, pH and HCO3- in the pancreatic juice were determined. More efficient drainage was obtained with the authors' method. However, due to the longer collection of pancreatic juice multielectrolytic compensation liquids had to be used in the animals to maintain acid-base equilibrium and to prevent the risk of metabolic acidosis.