A gene highly homologous to ACP1 encoding cysteine proteinase 3 in Entamoeba histolytica is present and expressed in E. dispar

Parasitol Res. 1996;82(2):189-92. doi: 10.1007/s004360050093.

Abstract

We have cloned the complete gene encoding cysteine proteinase 3 in E. histolytica as well as a cDNA encoding a highly homologous protein in E. dispar. In addition, we have demonstrated the presence and expression of the CP3 gene in various E. histolytica and E. dispar isolates. Since the expression of the gene is rather similar within both Entamoeba species, we assume that it does not constitute the proposed virulence factor of E. histolytica.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cysteine Endopeptidases / genetics*
  • DNA, Protozoan / genetics
  • Entamoeba / metabolism*
  • Entamoeba histolytica / enzymology*
  • Gene Expression
  • Genes, Protozoan*
  • Molecular Sequence Data
  • Protozoan Proteins / genetics*
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid

Substances

  • DNA, Protozoan
  • Protozoan Proteins
  • Cysteine Endopeptidases

Associated data

  • GENBANK/X87213
  • GENBANK/X87214