The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans

J Bacteriol. 1996 Oct;178(19):5850-2. doi: 10.1128/jb.178.19.5850-5852.1996.

Abstract

The Candida albicans HOG1 gene (HOG1CA) was cloned by functional complementation of the osmosensitive phenotype associated with Saccharomyces cerevisiae hog1 delta mutants. HOG1CA codes for a 377-amino-acid protein, 78% identical to S. cerevisiae Hog1p. A C. albicans hog1 null mutant was found to be sensitive to osmotic stress and failed to accumulate glycerol on high-osmolarity media.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological / genetics
  • Calcium-Calmodulin-Dependent Protein Kinases / genetics*
  • Candida albicans / genetics*
  • Cloning, Molecular
  • Genes, Fungal*
  • Genetic Complementation Test
  • Glycerol / metabolism*
  • Mitogen-Activated Protein Kinases*
  • Molecular Sequence Data
  • Mutagenesis, Insertional
  • Osmotic Pressure
  • Phenotype
  • Saccharomyces cerevisiae Proteins*
  • Sequence Analysis, DNA
  • Signal Transduction / genetics

Substances

  • Saccharomyces cerevisiae Proteins
  • Calcium-Calmodulin-Dependent Protein Kinases
  • HOG1 protein, S cerevisiae
  • Mitogen-Activated Protein Kinases
  • Glycerol

Associated data

  • GENBANK/X90586