Lymphocyte dynamics, apoptosis and HIV infection

S D Frost; C A Michie

doi:10.1016/0966-842X(96)81516-2

Lymphocyte dynamics, apoptosis and HIV infection

Trends Microbiol. 1996 Feb;4(2):77-82. doi: 10.1016/0966-842X(96)81516-2.

Authors

S D Frost¹, C A Michie

Affiliation

¹ Department of Zoology, Oxford University, UK, sfrost@vax.ox.ac.uk

PMID: 8820572
DOI: 10.1016/0966-842X(96)81516-2

Abstract

Death of HIV-infected CD4+ cells and HIV-induced death of uninfected CD4+ cells by apoptosis have been suggested to be important factors in causing the gradual progressive decline of CD4+ cells in the blood of HIV-positive patients. Recent advances in our knowledge of the dynamics of infection and the mechanism of apoptosis are reviewed with the aid of a mathematical model.

Publication types

Review

MeSH terms

Apoptosis*
CD4-Positive T-Lymphocytes / virology*
HIV Infections / immunology*
HIV* / immunology
HIV* / pathogenicity
Humans
Kinetics
Models, Immunological
Virus Replication