Abstract
The aim of the present clinical double-blind crossover study was to investigate the effect of two different toothpaste detergents, sodium lauryl sulfate (SLS) and cocoamidopropyl betaine (CAPB), as compared with a detergent-free paste, on 30 patients with frequent occurrences of recurrent aphthous ulcers. The study consisted of three 6-week periods during which the patients brushed twice daily with the different test toothpastes. The localization and number of new ulcers were assessed. A significantly higher frequency of aphthous ulcers was demonstrated when the patients brushed with an SLS- than with a CAPB-containing or a detergent-free placebo paste. An SLS-free toothpaste may thus be recommended for patients with recurrent aphthous ulcers.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adolescent
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Adult
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Aged
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Betaine / analogs & derivatives*
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Betaine / pharmacology
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Child
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Cross-Over Studies
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Detergents / adverse effects
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Detergents / pharmacology*
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Double-Blind Method
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Female
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Humans
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Male
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Middle Aged
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Placebos
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Recurrence
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Sodium Dodecyl Sulfate / adverse effects
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Sodium Dodecyl Sulfate / pharmacology*
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Stomatitis, Aphthous / etiology*
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Stomatitis, Aphthous / pathology
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Stomatitis, Aphthous / physiopathology
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Surface-Active Agents / adverse effects
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Surface-Active Agents / pharmacology*
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Toothpastes / adverse effects
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Toothpastes / pharmacology*
Substances
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Detergents
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Placebos
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Surface-Active Agents
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Toothpastes
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Sodium Dodecyl Sulfate
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Betaine
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cocamidopropyl betaine