Abstract
Cellulose acetate butyrate microparticles loaded in carbamazepine were prepared by a solvent evaporation technique. A decrease of the amount of organic solvent (from 80 to 40 ml of methylene chloride) increased the microparticle average diameter (73-111 and 207 microns) and decreased the carbamazepine release rate (T50% increased from 3.3 to 16.8 and 166.4 min). The microparticle area under the curve at 120 min was similar to that obtained with Tegretol LP 200 tablets.
MeSH terms
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Capsules
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Carbamazepine / administration & dosage*
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Carbamazepine / chemistry
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Cellulose / analogs & derivatives*
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Cellulose / chemistry
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Chemistry, Pharmaceutical
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Delayed-Action Preparations
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Methylene Chloride
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Particle Size
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Polymers / chemistry*
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Sodium Dodecyl Sulfate
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Solubility
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Solvents
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Surface-Active Agents
Substances
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Capsules
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Delayed-Action Preparations
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Polymers
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Solvents
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Surface-Active Agents
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Carbamazepine
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Sodium Dodecyl Sulfate
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Methylene Chloride
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Cellulose
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cellulose acetate-butyrate