Keeping the centrosome cycle on track. Genome stability

M Winey

doi:10.1016/s0960-9822(02)00639-5

Keeping the centrosome cycle on track. Genome stability

Curr Biol. 1996 Aug 1;6(8):962-4. doi: 10.1016/s0960-9822(02)00639-5.

Author

M Winey¹

Affiliation

¹ Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Campus Box 347, Boulder, 80309-0347, USA.

PMID: 8805324
DOI: 10.1016/s0960-9822(02)00639-5

Abstract

The protein kinase Mps1 and p53 both function in centrosome duplication and the spindle cell-cycle checkpoint. Defects in these functions can be potent sources of genomic instability by allowing mitosis to proceed with aberrant mitotic spindles.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Centrosome*
Genome, Fungal*
Protein Serine-Threonine Kinases / physiology
Protein-Tyrosine Kinases / physiology
Saccharomyces cerevisiae / genetics*
Saccharomyces cerevisiae Proteins*
Tumor Suppressor Protein p53 / physiology

Substances

Saccharomyces cerevisiae Proteins
Tumor Suppressor Protein p53
Protein-Tyrosine Kinases
Protein Serine-Threonine Kinases
MPS1 protein, S cerevisiae