Abstract
Three new cytotoxic sesterterpenes, 1-3, have been isolated from the marine sponge Hyrtios cf. erectus. Their structures have been determined by interpretation of NMR data. They exhibited cytotoxicity against P-388 murine leukemia cells with IC50 values of 0.4-2.1 micrograms/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Leukemia P388 / drug therapy
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Magnetic Resonance Spectroscopy
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Mice
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Porifera / chemistry*
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Sesterterpenes
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Ultraviolet
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
Substances
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Antineoplastic Agents
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Sesterterpenes
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Terpenes