Three new cytotoxic sesterterpenes from the marine sponge Hyrtios cf. erectus

J Nat Prod. 1996 May;59(5):515-7. doi: 10.1021/np960130e.

Abstract

Three new cytotoxic sesterterpenes, 1-3, have been isolated from the marine sponge Hyrtios cf. erectus. Their structures have been determined by interpretation of NMR data. They exhibited cytotoxicity against P-388 murine leukemia cells with IC50 values of 0.4-2.1 micrograms/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Leukemia P388 / drug therapy
  • Magnetic Resonance Spectroscopy
  • Mice
  • Porifera / chemistry*
  • Sesterterpenes
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Ultraviolet
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology

Substances

  • Antineoplastic Agents
  • Sesterterpenes
  • Terpenes