Impaired nitrergic relaxation of the sphincter of Oddi of hyperlipidaemic rabbits

Z Szilvassy; I Nagy; J Szilvassy; I Jakab; S Csati; J Lonovics

doi:10.1016/0014-2999(96)00159-8

Impaired nitrergic relaxation of the sphincter of Oddi of hyperlipidaemic rabbits

Eur J Pharmacol. 1996 Apr 22;301(1-3):R17-8. doi: 10.1016/0014-2999(96)00159-8.

Authors

Z Szilvassy¹, I Nagy, J Szilvassy, I Jakab, S Csati, J Lonovics

Affiliation

¹ First Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.

PMID: 8773472
DOI: 10.1016/0014-2999(96)00159-8

Abstract

Field stimulation relaxed the sphincter of Oddi muscle rings of the rabbit after incubation with phentolamine, oxprenolol and atropine (all 1 microM). The relaxation was blocked by NG-nitro-L-arginine methyl ester (30 microM) and was reversed by 3 mM L-arginine but not D-arginine. Sphincter of Oddi preparations from hypercholesterolaemic rabbits exhibited contractions under the same conditions. We conclude that nitrergic relaxation is impaired in the sphincter of Oddi from hypercholesterolaemic rabbits.

MeSH terms

Animals
Cholesterol, Dietary / pharmacology
Electric Stimulation
Enzyme Inhibitors / pharmacology
Hypercholesterolemia / physiopathology*
In Vitro Techniques
Male
Muscle Relaxation / drug effects
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / physiology*
Nitric Oxide Synthase / antagonists & inhibitors
Rabbits
Sphincter of Oddi / drug effects
Sphincter of Oddi / physiopathology*

Substances

Cholesterol, Dietary
Enzyme Inhibitors
Nitric Oxide
Nitric Oxide Synthase
NG-Nitroarginine Methyl Ester