Haplotypic association of two new HLA class I alleles: Cw*15052 and B*0706: evolutionary relationships of HLA-Cw*15 alleles

Tissue Antigens. 1996 Apr;47(4):329-32. doi: 10.1111/j.1399-0039.1996.tb02561.x.

Abstract

A novel HLA-Cw*15, B7 haplotype has been found in Caucasians. Molecular cloning studies demonstrate that this haplotype is constituted by the new alleles Cw*15052 and B*0706, which seem to be intermediate steps in the diversification of their respective allelic families. A pathway for the evolution of Cw*15 alleles is proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Base Sequence
  • HLA Antigens / genetics*
  • Haplotypes
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction / methods

Substances

  • HLA Antigens

Associated data

  • GENBANK/X87841
  • GENBANK/X91749