Quinazolinone derivatives: synthesis and binding evaluation on cholecystokinin receptors

Farmaco. 1996 May;51(5):333-9.

Abstract

A series of 2-methyl-3-amino-4(H)-quinazolinone and of 2-phenyl-3-amino-4(H)-quinazolinone derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-B rather than CCK-A receptor and the obtained results confirm that the 4(3H)-quinazolinone nucleous represent a useful template for the development of selective CCK-B receptor ligands.

MeSH terms

  • Animals
  • Cerebral Cortex / metabolism
  • Chemical Phenomena
  • Chemistry, Physical
  • Guinea Pigs
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Male
  • Mass Spectrometry
  • Pancreas / metabolism
  • Quinazolines / chemical synthesis*
  • Quinazolines / chemistry
  • Quinazolines / pharmacokinetics
  • Radioligand Assay
  • Rats
  • Rats, Wistar
  • Receptors, Cholecystokinin / drug effects
  • Receptors, Cholecystokinin / metabolism*
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Quinazolines
  • Receptors, Cholecystokinin