Abstract
A series of 2-methyl-3-amino-4(H)-quinazolinone and of 2-phenyl-3-amino-4(H)-quinazolinone derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-B rather than CCK-A receptor and the obtained results confirm that the 4(3H)-quinazolinone nucleous represent a useful template for the development of selective CCK-B receptor ligands.
MeSH terms
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Animals
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Cerebral Cortex / metabolism
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Chemical Phenomena
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Chemistry, Physical
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Guinea Pigs
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Male
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Mass Spectrometry
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Pancreas / metabolism
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Quinazolines / chemical synthesis*
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Quinazolines / chemistry
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Quinazolines / pharmacokinetics
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Radioligand Assay
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Rats
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Rats, Wistar
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Receptors, Cholecystokinin / drug effects
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Receptors, Cholecystokinin / metabolism*
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Quinazolines
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Receptors, Cholecystokinin