Objective: To investigate the value of color doppler flow imaging (CDFI) and pulsed doppler (PD) determinations in early diagnosis, evaluation of therapeutic effects and prediction of prognosis of gestational trophoblastic diseases (GTD).
Method: CDFI and PD were performed in 55 cases of GTD and 30 normal pregnant women as controls.
Results: The uterine muscular layer in GTD showed multicolored abundant blood flow and blood sinuses. Blood flow resistance was low with a resistance index (RI) less than 0.5. After chemotherapy the RI changed dramatically. Pathological evidences were found in surgical specimens of 8 patients. Findings of pelvic hysterography in 16 cases were in accordance with the results of CDFI and PD determinations.
Conclusion: CDFI and PD as new methods for early diagnosis of GTD can also be used to evaluate the chemotherapeutic results as well as to determine the prognosis of the disease.