Vitamin E deficiency in organism leads to microsome membrane phospholipid composition changes, oxidation, superoxide dismutase (SOD) activity decrease, accompanied with the disorders of lung and liver tissues functional state which is connected with regulation of membrane penetration. The negative effect of E-hypovitaminosis more affects the liver than lung, which is caused by their different functional purposes, peculiarities of metabolic processes as well as by the content of biomembrane structural components. Vitamin E protects phospholipids from oxidation, regulates AOS condition, SOD-activity and promotes in such way the tissue functional disturbances correction of the animals tested. New preparation "Calmophyl" is a phospholipid complex from marine organisms with surfactant-kind effect, which displays antioxidative properties and decreases toxic affect of CCl4, corrects functional tissue disorders, regenerates normal activity of enzymes. Preparation of natural phospholipids has been shown to be capable to stabilize cell membranes probably by means of replacing the membrane phospholipid composition and decreasing disturbances in the antioxidative system.